Differential PKA activation and AKAP association determines cell fate in cancer cells
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چکیده
منابع مشابه
Differential PKA activation and AKAP association determines cell fate in cancer cells
BACKGROUND The dependence of malignant properties of colorectal cancer (CRC) cells on IGF1R signaling has been demonstrated and several IGF1R antagonists are currently in clinical trials. Recently, we identified a novel pathway in which cAMP independent PKA activation by TGFβ signaling resulted in the destabilization of survivin/XIAP complex leading to increased cell death. In this study, we ev...
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ژورنال
عنوان ژورنال: Journal of Molecular Signaling
سال: 2013
ISSN: 1750-2187
DOI: 10.1186/1750-2187-8-10